Gaucher’s disease Type I effect
(or non-neuropathic type) is the most common form of the disease,
occurring in approximately 1 in 50,000 live births. It occurs most often
among persons of Ashkenazi Jewish heritage. Symptoms may begin early in
life or in adulthood and include enlarged liver and grossly enlarged
spleen (together hepatosplenomegaly); the spleen can rupture and cause
additional complications.
Skeletal
Gaucher’s disease Type I effect and bone disease
may be extensive. Spleen enlargement and bone marrow replacement cause
anemia, thrombocytopenia and leukopenia. The brain is not affected
pathologically, but there may be lung and, rarely, kidney impairment.
Patients in this group usually bruise easily (due to low levels of
platelets) and experience fatigue due to low numbers of red blood cells.
Depending on disease onset and severity, type 1 patients may live well
into adulthood. Many patients have a mild form of the disease or may not
show any symptoms. ( Definition
wikipedia about
Gaucher’s disease Type I effect ).
